IDENTIFICATION OF KEY ERNAS FOR INTERVERTEBRAL DISC DEGENERATION BY INTEGRATED MULTINOMIAL BIOINFORMATICS ANALYSIS

Identification of key eRNAs for intervertebral disc degeneration by integrated multinomial bioinformatics analysis

Abstract Background Intervertebral disc degeneration (IVDD) is a common degenerative condition leading to abnormal stress distribution under load, causing intervertebral stenosis, facet joint degeneration, and foraminal stenosis.Very little is known about the molecular mechanism of eRNAs in IVDD.Methods Gene expression profiles of 38 annulus disc s

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Stochastic simulations of the Schnakenberg model with spatial inhomogeneities using reactive multiparticle collision dynamics

A numerically efficient globally averaged number density approach is used to simulate a reaction-diffusion system using a particle-based stochastic simulation algorithm called reactive multiparticle collision (RMPC) dynamics.Constant diffusivity of the particles is achieved through a time-varying rotation angle (also called collision angle).Variati

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